Docking, Synthesis and Anti- Diabetic Activity of Novel Derivatives Sulfonylhydrazone Designed the PPAR Gamma Agonists
Summary : Diabetes is a metabolic disease with serious complications such as neuropathy, heart disease and kidney failure. Various substances are used in the treatment but has side effects and do not prevent the onset of long-term complications. This work describes the synthesis of new derivatives sulfonilhidrazona designed as PPARgamma agonists and tested for hypoglycemic effect in a murine model of diabetes.

LASSBio -294 , The Compound With Inotropic and Lusitropic Activity , Decreases Cardiac Remodeling and Improves Ca2 + Influx Into Sarcoplasmic Reticulum After Myocardial Infarction
Summary : Myocardial infarction is associated with cardiac hypertrophy , reduced uptake of calcium by sarcoplasmic reticulum and ventricular dysfunction . Treatment to prevent complications of coronary disease does not exist. The purpose of this study is to investigate the remodeling and cardiac function in animal models of myocardial infarction after treatment with new derivative tienilhidrazona.

Benzenesulfonamide attenuates pulmonary arterial monocrotaline -induced hypertension in a rat model
Abstract: This study evaluated the effects of LASSSSBio -965 ( N- [2- (3,4- dimethoxyphenyl ) ethyl ] -benzene- sulfonamide ) in vascular smooth muscle cells in vitro as well as in animal models of pulmonary hypertension induced by monocrotaline . This derivative promoted vascular relaxation in a concentration- dependent manner , and reduced the alterations in pulmonary hypertension by inhibiting phosphodiesterase type 3 , 4 and 5.

Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound
Summary: LASSBio -985 is a sulfonamide derivative intended to be inhibitors of phosphodiesterase enzymes responsible for the degradation of cyclic nucleotides. LASSBio -985 produced vasodilation in vessels from hypertensive animals normo- and by inhibiting phosphodiesterase type 1 and calcium channel blockade. Intravenous infusion of this derivative significantly reduced blood pressure in hypertensive animals.

And Vasodilator antihypertensive effects of a novel N- acylhydrazone derivative mediated by the inhibition of L -type Ca2 + channels
Summary: This paper describes the cardiovascular effects of new derivative N- acylhydrazone , LASSBio -1289 . Antihypertensive action was observed during treatment with LASSBio -1289 in hypertensive animals due to its vasodilating effect mediated by inhibition of calcium influx through calcium channels dependent voltage.